Molecular Basis of Inheritance is a Class 12 Biology chapter that carries about 6.2% of the Biology questions in NEET. Practise it with 73 questions covering 7 topics, each with an explanation.
Sample questions on Molecular Basis of Inheritance with answers
8 questions from the practice bank, spread across the chapter's topics. The full set is in the app.
Question 1: DNA Replication
Okazaki fragments are short DNA segments formed during:
- A Transcription
- B Translation
- C DNA replication
- D DNA repair
Answer: C. DNA replication
Why: Because DNA polymerase synthesizes only in the 5'→3' direction, the lagging strand is replicated discontinuously in short segments called Okazaki fragments, later joined by DNA ligase.
Question 2: DNA Structure and Packaging
A nucleosome consists of about 200 base pairs of DNA wound around:
- A a non-histone protein
- B a histone octamer of H1 only
- C a histone octamer, with two molecules each of H2A, H2B, H3 and H4
- D an RNA molecule
Answer: C. a histone octamer, with two molecules each of H2A, H2B, H3 and H4
Why: Histone H1 binds the linker DNA between nucleosomes.
Question 3: Gene Expression Regulation (Lac Operon)
In the lac operon, the gene i codes for:
- A permease
- B the repressor protein
- C β-galactosidase
- D RNA polymerase
Answer: B. the repressor protein
Why: The repressor binds to the operator.
Question 4: Genetic Code
H. G. Khorana contributed to the cracking of the genetic code by:
- A discovering DNA
- B finding reverse transcriptase
- C isolating ribosomes
- D chemically synthesising RNA molecules with defined repeating sequences
Answer: D. chemically synthesising RNA molecules with defined repeating sequences
Why: He used them to find which amino acids each codon specified.
Question 5: Human Genome Project and DNA Fingerprinting
The Human Genome Project aimed to determine:
- A the complete sequence of the 3 × 10⁹ base pairs of the human genome
- B the structure of proteins only
- C the number of chromosomes only
- D the age of humans
Answer: A. the complete sequence of the 3 × 10⁹ base pairs of the human genome
Why: The project was completed in 2003.
Question 6: Transcription
The strand of DNA that has the same base sequence as the mRNA (with T in place of U) is the:
- A Okazaki strand
- B primer
- C template strand
- D coding (non-template) strand
Answer: D. coding (non-template) strand
Why: The template strand is read by the RNA polymerase.
Question 7: Translation
A polysome (polyribosome) is:
- A a collection of nucleosomes
- B a group of ribosomes attached to a single mRNA
- C a ribosome with many tRNAs
- D a group of mRNAs on one ribosome
Answer: B. a group of ribosomes attached to a single mRNA
Why: It allows many copies of the polypeptide to be made at the same time.
Question 8: DNA Replication
The strand of DNA that is synthesised continuously during replication is the:
- A leading strand
- B lagging strand
- C template strand only
- D coding strand only
Answer: A. leading strand
Why: The lagging strand is made as Okazaki fragments.